TB-500

Q: What's the actual amount in each vial?

Each vial contains exactly what’s shown on the label. For example, a 10mg vial has exactly 10mg of lyophilized peptide. Researchers can divide it into smaller portions—like four 2.5mg measurements—but the total amount remains 10mg.

Q: Are additional supplies needed?

Peptides are supplied as lyophilized powder. They do not come reconstituted, and any extra supplies must be sourced separately for research applications.

Q: How long does a vial last?

In lyophilized powder form, peptides stay stable for up to 2 years. After reconstitution, it should be refrigerated and is generally stable for up to 2 months.

Q: Does the product come with instructions?

Products from us do not include usage instructions, as they are strictly for in vitro research and prohibited by law for human or animal use. Misuse or unlawful application will result in permanent denial of service.

Q: How should I store these products?

Lyophilized peptides should be stored away from heat and light. Once reconstituted, they must be refrigerated to maintain stability and efficacy.

V251230-9-010

Price range: $59.99 through $491.99

Strength + Bundles

Clear

Research Use Only

All products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.

Certificate of Analysis

Third-party tested for 99% purity, ID, quantity.

Certificate of Analysis

Third-party tested for endotoxins

TB-500 Overview

TB-500 is a synthetic peptide fragment derived from thymosin beta-4, a naturally occurring protein studied for its role in molecular signaling and pathway dynamics. Research has focused on its potential influence on matrix remodeling, angiogenesis, and molecular migration in preclinical and laboratory models. TB-500 is of particular interest in investigations involving connective tissue, structural dynamics, and extracellular matrix pathways.

Goldstein A.L. et al. (2005).??

History

Thymosin Beta-4, the parent protein of TB-500, was first isolated in the 1960s by Allan L. Goldstein and colleagues during research into thymus-derived peptides. TB-500 was later synthesized as a research fragment to enable focused study on T??4’s signaling functions. Since its development, it has been investigated across models of angiogenesis, structural dynamics, and molecular migration, with growing interest in its systemic regulatory potential.

Goldstein A.L., Hannappel E. et al. (2012).

TB-500 Structure

CAS# V251230-9-010
Molecular Formula: C?????????H?????????N??????O?????

Research Findings

TB-500 has been studied in structural, vascular, epithelial, and systemic models, with research exploring its roles in collagen organization, extracellular matrix remodeling, angiogenesis, molecular migration, and pathway activity in preclinical settings.

Key Areas of Research:

Structural: Collagen, matrix, tendon/ligament
Vascular: Angiogenesis, nitric oxide, remodeling
Epithelial: Migration, signaling, matrix
Systemic: Signaling, viability, pathway dynamics

Together, these findings suggest broad experimental utility for TB-500 across multiple biological pathways. By engaging structural and vascular processes and supporting epithelial and systemic responses, TB-500 provides a versatile platform for investigating molecular remodeling, pathway dynamics, and resilience in laboratory settings.

Hsieh M.-J. et al., 2017

References

Goldstein A.L. et al. (2005). Thymosin beta-4 and tissue regeneration: potential mechanisms of action. Ann N Y Acad Sci.

Goldstein A.L., Hannappel E. et al. (2012). Thymosin beta-4: a multifunctional regenerative peptide. Expert Opin Biol Ther, 12(1):37???51.

Malinda K.M. et al. (1999). Thymosin beta-4 stimulates directional migration of human umbilical vein endothelial cells. FASEB J, 13(6):693???701.

Smart N. et al. (2007). Thymosin beta-4 induces adult epicardial progenitor mobilization and neovascularization. Nature, 445(7124):177???182.

Philp D. et al. (2003). Thymosin beta-4 promotes dermal wound healing. J Invest Dermatol, 121(4):694???701.??

“framer-text framer-styles-preset-pl80se”>Bock-Marquette I. et al. (2004). Thymosin beta-4 activates integrin-linked kinase and promotes cardiac cell migration, survival, and repair. Nature, 432(7016):466???472.</

Our Process

STEP 1

Precision Lyophilization

Manufactured in a controlled U.S. facility under strict compounding standards.

STEP 2

Verified Purity

Every batch third-party tested with HPLC and mass spectrometry.

STEP 3

Same-Day Fulfillment

Orders dispatched same-day from our
U.S. facility.

STEP 1

Precision Lyophilization

Manufactured in a controlled U.S. facility under strict compounding standards.

STEP 2

Verified Purity

Every batch third-party tested with HPLC and mass spectrometry.

STEP 3

Same-Day Fulfillment

Orders dispatched same-day from our
U.S. facility.

Text us, our dedicated team is here to help

Reach out and get a response within minutes.

Frequently Asked Questions

Everything you need to know about our products and processes.

What's the actual amount in each vial?

Each vial contains exactly what’s shown on the label. For example, a 10mg vial has exactly 10mg of lyophilized peptide. Researchers can divide it into smaller portions—like four 2.5mg measurements—but the total amount remains 10mg.

Are additional supplies needed?

Peptides are supplied as lyophilized powder. They do not come reconstituted, and any extra supplies must be sourced separately for research applications.

How long does a vial last?

In lyophilized powder form, peptides stay stable for up to 2 years. After reconstitution, it should be refrigerated and is generally stable for up to 2 months.

Does the product come with instructions?

Products from us do not include usage instructions, as they are strictly for in vitro research and prohibited by law for human or animal use. Misuse or unlawful application will result in permanent denial of service.

How should I store these products?

Lyophilized peptides should be stored away from heat and light. Once reconstituted, they must be refrigerated to maintain stability and efficacy.